Professor Gibin Powathil

I am currently a Professor of Mathematics at the Department of Mathematics, Swansea University, United Kingdom. My primary research interests are in Mathematical Biology and Mathematical Oncology. In particular, I am interested in multiscale mathematical modelling of cancer and associated therapies, which will eventually help towards Model Assisted Personalised Medicine. These mathematical and computational models can be very helpful in gaining valuable insights into the mechanisms and consequences of various complex intracellular and intercellular changes during and after therapy.

I received my PhD in Applied Mathematics from the University of Waterloo, Canada and my thesis was on mathematical modelling of brain tumours. I have a MSc (by Research) in Computational Mathematics from National University of Singapore and MSc in Mathematics from Indian Institute of Technology, Madras. Prior to this post I was working with Professor Mark Chaplain, Division of Mathematics, University of Dundee, Scotland as a postdoctoral research assistant.

I am Co-Director of Centre for Biomathematics at Swansea University and Head of Mathematics at Swansea university.

 

Current Employment

2023-current: Professor, Department of Mathematics, Swansea University

 Previous Employment

2019 – 2023: Associate Professor, Department of Mathematics, Swansea University

2014 – 2019: Senior Lecturer, Department of Mathematics, Swansea University

2009 – 2014: Postdoctoral Research Assistant, Department of Mathematics, University of Dundee

 Educational Qualifications

2018- Postgraduate Certificate in Higher Education, Swansea University, UK

2004-2009: PhD Applied Mathematics, University of Waterloo, Canada

2003-2004: MSc (by Research) Computational Mathematics, National University of Singapore

2001-2003: MSc Mathematics (1st Rank, CGPA 8.94/10), IIT Madras, India

1998-2001: BSc Mathematics (1st Rank, 98.2% marks), M G University, Kerala, India

Leadership, Management and Committees

2024- Present: Head, Department of Mathematics

2025- Present: Co-Director, Biomathematics Centre

2023 – Present: Co-Lead Foundation and Methods for Modelling, Data Science and AI Theme, Zienkiewicz Institute for Modelling, Data and AI

2022 – 2024: Deputy Head, Mathematics

2022 – 2024: EPSRC Impact Acceleration Award Subcommittee Member

2021- 2025: Deputy Co-Director, Biomathematics Centre

2021 – 2024: Admissions Co-lead, Mathematics

2020 – 2024:  Department Outreach Officer

2020- 2023 Secretary, Society for Mathematical Biology

2017 – 2020: Departmental Research Committee

2018 – 2023 HDR UK (Health data research UK) cite representative

2016 – Present: Swansea REF UoA (Research Excellence Framework, Unit of Assessment) Working Group

2016 – 2025: Swansea REF UoA Impact Lead

  • Mathematical modelling of cancer progression and treatment strategies
  • Drug delivery, optimal sequencing and scheduling of cancer therapies
  • Discrete and hybrid computational models in cancer growth
  • Modelling inter- and intra-cellular dynamics
  • Studying radiation and radiation bystander effects
  • Radioecology

 My research is very much interdisciplinary and some of the main highlights of my research include:

  • Development of Multiscale Modelling Framework: I am currently developing an individual-cell based multiscale modelling framework to study the growth and progression of cancel cells and their reposes to therapy. This is framework is currently being used by several external research groups to study Tuberculosis, 3D cell printing and cancer treatment response. The model and the framework is continuously being updated.
  • Involvement in Radioecology: I am currently involved in a focussed radioecology subgroup supported by International Union of Radioecology. The overall aim of the subgroup is to understand the effects of radiation (primarily low dose radiation) in an ecological context. 
  • Clinical and Industrial Collaboration: I work closely with clinical and experimental groups with an aim to develop a biologically and clinically relevant mathematical and computational models. My collaborators include South West Wales Cancer Centre and Institute of Cancer Research. Recently, I started working with AstraZeneca to study the effects of an anticancer drug and GSK to study HIV treatment modelling.

(Declined invitations (due to personal and professional reasons) are not listed here)

  • Plenary Speaker: The inaugural edition of the UK Mathematical Biology Conference, University of Birmingham, UK (September 2025)
  • Invited Speaker: Mathematical Foundations of Oncological Digital Twins Isaac Newton Institute of Mathematical Sciences, Cambridge, UK (September 2025)
  • Invited Talk, NATO Advanced Research Workshop on Low dose radiation risks: present research and future perspectives, Yerevan, Armenia (March 2025) – Invited speaker to lead modelling session.
  • Invited Lecture and Talk, 3MC+PIMS+ICMS Winter school – Multiscale Modeling: Infectious Diseases, Cancer and Treatments, ICMS- Bayes Centre, Edinburgh, UK (2024).
  • Invited Lecture and Talk, Theoretical approaches in cancer progression and treatment, International Centre for Theoretical Sciences (ICTS), Bangalore, India (2024).
  • Invited Seminar Talk, Department of Mathematics, Vellore Institute of Technology, Chennai, India (2022)
  • Invited Panel Member, DEI Panel discussion: Annual SMB Conference, Heidelberg (2022)
  • Invited Talk (virtual), CMO-BIRS Workshop “Modeling and Computational Approaches to Individual and Collective Cell Movement in Complex Environments” (September-October 2021).
  • Seminar Talk (virtual), Mathematics Department, Karlstads University, Sweden (September 2020)
  • Invited Talk, South Wales Applied Mathematics for Biomedical Advances, Cardiff University, Cardiff, UK (January 2020)
  • Invited Talk, Mathematical Oncology Mini-symposium, Annual Society of Mathematical Biology Conference, Montreal (July 2019)
  • Seminar Talk, Centre for BioSystems Science and Engineering, Indian Institute of Science, India (December 2019)
  • Seminar Talk, Department of Mathematics, Cardiff University, Cardiff, UK (January 2019)
  • Co-Chair, Radioecology Workshop, 16th International Congress for Radiation Research, Manchester (August 2019)
  • Invited Talk, International Union of Radioecology Workshop on “Low-dose radiation effects on the ecosphere; are high dose and dose rate data good predictors”, University of Stirling, UK (July 2018) – Invited speaker to lead on modelling. This meeting resulted in a joint paper
  • Invited Talk, NATO Advanced Research Workshop on Biomarkers of radiation in the environment, Yerevan, Armenia (November 2017) – Invited speaker to lead modelling session. This participation resulted in a contributed chapter that will be published in NATO Advanced Research series book and a joint policy paper
  • Invited Talk, Radiobiology meets Radioecology: the impact of recent research on our understanding of the effects of radiation in the environment, workshop “Radiobiology meets Radioecology”, University of Essen (July 2017)- This meeting resulted in a paper
  • Invited Talk, Two mini-symposiums, Annual meeting of Society of Mathematical Biology, Nottingham, UK (July 2016)
  • Invited Talk, Workshop on Mathematical Modelling and Computation in Medicine/Biology, Tsinghua Sanya International Mathematics Forum, Sanya, China (December 2016)
  • Invited Talk, Workshop on Mathematical Oncology, Fields Institute, Canada (April 2016) – Invited Speaker
  • Invited talk. Workshop on Modelling Bystander Effects for Biomedical and Environmental Research, University of Stirling, UK (April 2015) Lead modelling speaker. This meeting resulted in a joint paper on advising the future research direction published in “Environmental Research”
  • Invited Talk, Mini-symposium on “Spatial Models in Cancer Biology” at European Society of Mathematical and Theoretical Biology and Society of Mathematical Biology, June 16 – June 19, 2014, Gothenburg, Sweden
  • Invited Talk, Mini-symposium on “Math-bio-Applications of Cellular Potts Model” at Euro- pean Society of Mathematical and Theoretical Biology and Society of Mathematical Biology, June 16 – June 19, 2014, Gothenburg, Sweden
  • Invited Talk, Workshop on Mathematical Oncology V, March 27 – 29, 2014, Fields Institute, Toronto, Canada
  • Contributed Talk, British Applied Mathematics Colloquium, April 9 – 12, 2013, Leeds, UK (Abstract published)
  • Poster Presentation, San Antonio Breast Cancer Symposium 2012, Dec 4 – 8, 2012, San Antonio, USA (Abstract published)
  • Invited Talk, The 2012 Annual Meeting of the Canadian Applied and Industrial Mathematics Society, June 24 – 28, 2012, Toronto, Canada (Abstract published)
  • Invited Talk, Present Challenges of Mathematics in Oncology and Biology of Cancer: Modelling and Mathematical Analysis, March 19 – 23, 2012, CIRM, Marseille, France (Abstract published)
  • Contributed Talk, An international meeting on radiation induced cancer and non-cancer diseases, October 16 – 18, 2011, The Royal Swedish Academy of Sciences, Stockholm, Sweden (Abstract published)
  • Contributed Talk, Joint Conference of European Society of Mathematical and Theoretical Biology and Society of Mathematical Biology, June 28 – July 2, 2011, Krakow, Poland (Abstract published)
  • Poster Presentation, EPSRC Durham Symposium: Numerical Analysis of Multiscale Problems, July 5 – 15, 2010, Durham, UK
  • Contributed Talk, British Mathematical Colloquium and British Applied Mathematics Colloquium, April 6 – 9, 2010, Edinburgh, UK (Abstract published)
  • Invited Talk, Workshop on Mathematical Oncology III, March 18 – 20, 2010, Fields Institute, Toronto, Canada
  • Divisional Seminar, February 2010, Division of Mathematics, University of Dundee, Dundee, UK
  • Invited Talk, Division of Mathematics, University of Dundee, March 2009, Dundee, UK
  • Invited Talk, Integrated Mathematical Oncology, Moffitt Cancer Center, April 2009, Florida.

Teaching and Learning Activities:

  • 2018 Postgraduate Certificate in Higher Education, Swansea University, UK
  • 2018 Fellow of Higher Education Academy, UK
  • 2018: Invited Talk: Swansea Learning and Teaching Conference
  • 2014 – Present: Swansea University: Developed applied and computational modules such as Numerical Analysis, Numerics of ODEs and PDEs, and Numerical Methods, Biomathematics, Introduction to Modelling and Simulation.
  • 2010 – 2014: University of Dundee: Mathematical Biology
  • Co- developed MSc Applied Data Science program
  • Co-developed MRes Modelling Data and AI
  • Academic Lead: Swansea-Indian Institute of Technology Madras Joint PhD program development
  • Nominated for teaching award in 2024 and 2023

Courses Taught:

Swansea: Biomathematics, Introduction to Modelling and Simulation, Numerics of ODEs and PDEs, Numerical Analysis, Mathematical Modelling: Theory and Practice, Modelling and Machine Learning, Further Methods of Algebra and Calculus, Computational Methods (with Matlab) and Numerical Methods (with Matlab).

            Dundee: Mathematical Biology

            Waterloo: Calculus

Research Publications:  Author of over 34 research papers with 1131 citations (h-index: 18, i10- index: 23)   (data from google scholar).

Conferences/Workshops/Seminars:  Participation in over 35 conferences or workshops with over 25 presentations given (15 invited).

Member of Newton International Fellowships Committee, The Royal Society

Editorial Memberships:

Editorial Board, Journal of Theoretical Biology

Editorial Board Member, npj Systems Biology and Applications

Section Editor, Mathematics in Medical and Life Sciences

Managing Editor, BMC Radiation Oncology

Associate Editor, AIMS Mathematical Biosciences and Engineering

Regular Referee:

Journal of Theoretical Biology, Bulletin of Mathematical Biology, Biotheoretica, PLOS Computational Biology, Cell reports, Journal of Mathematical Biology,            Cancer Research

Grant Review:

            MRC, Cancer Research UK: Multidisciplinary Award (17/12/2015, 4/1/2018),

            National Science Centre, Poland (Funding scheme PRELUDIUM, 7/9/2015),

            INSERM, France.

Industrial and External Engagement:

            Joint PhD student project with AstraZeneca (~£46000)

            Joint PhD student project with GlaxoSmithKline (GSK) (~£46000)

            Collaborations with NHS and Swansea Bay Health Board

Relevant Grants/Honours/Awards (selected)

  • “Lee Segel” prize for the best paper published in BMB in last two years (Hamis, S., Yates, J., Chaplain, M. A., & Powathil, G. G. (2021). Targeting cellular DNA damage responses in cancer: An in vitro-calibrated agent-based model simulating monolayer and spheroid treatment responses to ATR-inhibiting drugs. Bulletin of Mathematical Biology83(10))
  • CO-I: Welsh Government: COVID19 Epidemic Policy simulations for Wales: Integrating Spatial Structure and Routine Linked Health Data for Disease Modelling.
  • Global Wales Funding: Interactional Collaboration (awarded £5000)
  • Co-I: Health Data Research UK regional Centre Application (awarded~30 m)
  • Co-I: LMS Research in Groups: South Wales Mathematical Biology (South Wales-Cardiff-Swansea)
  • Swansea- Grenoble PhD studentship award 2017, 2020, 2024
  • Conference Grant, London Mathematical Society 2016 (Co-applicant)
  • Conference Grant from POEMS network (Predictive mOdelling for hEathecare technology through Maths) to organise a workshop on mathematical oncology and pharmacology 2016.
  • Swansea PhD studentship award 2016, 2020, 2021
  • College of Science Research Fund Award 2015, 2016 and 2017 (£4028.71 total)
  • Selected to present in the UK Parliament as a part of SET for Britain in 2015

 

Organisation of International Conferences:

2024- AI in HealthCare, Swansea University

2024- Mathematical Modelling of Cancer Treatments, Resistance, Optimization, Fields Institute, Toronto, Canada

2024 – Frontiers in Computational and Mathematical Medicine, Fields Institute, Toronto, Canad

2024- International Statistical Ecology Conference 2024, Swansea University.

2022- Workshop on Mathematical Medicine and Mathematical Oncology, Swansea University

2021- Organising Committee- Society for Mathematical Biology Annual Conference 2021, University of California, Riverside, USA

2019 and 2020- Programme Committee, International Symposium on Mathematical and Computational Oncology

2017 – Workshop on Mathematical Medicine and Mathematical Pharmacology, Swansea University (main organiser)

 

PhD Supervision

  • Dr Sara Hamis (awarded 2020): Multiscale Modelling and Analysis of Tumour Growth and Treatment Strategies (current: Research Fellow at University of St. Andrews)
  • Carla White (Awarded 2021): Contributions to mathematical pharmacology: New receptor theory with dimeric receptor models
  • Kira Pugh (Awarded 2024): A Multiscale Modelling Approach to Study the Effects and Responses of DNA Damage Response (DDR) Inhibitor Drugs
  • Kevin Spinicci (Grenoble-Swansea PhD Project, Awarded 2024)): Computational and Mathematical Approaches to Understand Cancer Cells Metabolism
  • Sam Oliver (expected 2025): Mathematical Modelling of Cancer-Adipocyte Interactions in Ovarian Cancer
  • Jonathan Davies (expected 2027): Modelling Tumour Immunotherapy: Investigating T-cell engaging therapies in Oncology
  • Damian Bimbenet (Grenoble-Swansea PhD Project, expected 2027): Mathematical and computational approaches to explore the reciprocal interaction between cell metabolism and radiation therapy in cancer
  • Carlos Valter Baptista De Lima (expected 2025, Co-Supervisor): Interaction modes in Education
  • Aeshah Mohammad A Al Muyid (expected 2025, Co-Supervisor): Mathematical models of tumour growth: the beyond mean-field approach
  • Amy Milne (expected 2025, Co-Supervisor): Modelling the spatial ecology of cancer
  • Liam Ryall-Friend (expected 2027, Co-Supervisor): Mathematical modelling the role of circulating tumour DNA in diagnosis and therapy